Bile Duct Cancer (Klatskin Tumor)

Cholangiocarcinoma involving the hepatic bifurcation are categorized as hilar bile duct cancer or Klatskin tumors.

The majority of tumors are perihilar involving the hepatic bifurcation. Bile duct cancer accounts for 3% of gastrointestinal malignancies yearly or 5,000 new cases a year.

Risk Factors

  • Primary Sclerosing Cholangitis (PSC)
  • Choledochal Cysts
  • Pyogenic Cholangiohepatitis
  • Biliary Parasites (Clonorchis sinensis)
  • Hepatolithiasis
  • Idiopathic

Histopathology (adenocarcinoma)

  • Sclerosing
  • Nodular
  • Papillary

Clinical Presentation

  • Abdominal pain
  • Jaundice
  • Anorexia
  • Weight loss

Preoperative Staging

  • Type 1- Below hepatic bifurcation
  • Type 2- At Hepatic bifurcation
  • Type 3- Extends up the right hepatic duct
  • Type 4- Extends up the left hepatic duct
Dr. Mark Fraiman discusses the surgical treatment of Klatskin Tumors or Bile Duct Cancer in Baltimore, MD.